Background and Objectives: Brolucizumab is a novel anti-vascular endothelial growth factor (VEGF), whose efficacy has been shown in the Hawk and Harrier phase 3 clinical studies.The goal of the present case series is to report initial results of brolucizumab intravitreal injections (IVI) on type 3 neovascularization in neovascular age-related macular degeneration (nAMD), evaluated by optical coherence tomography angiography (OCTA).Materials and Methods: This is a bicentric retrospective case series.
Patients with newly diagnosed type 3 MNV treated with brolucizumab IVI and at least 6 months follow-up were enrolled.OCTA en face images and B-scans were analyzed for lesions at baseline, 1 SR VANILLA month, 3 months, and 6 months.Whenever detectable, lesion area on outer retina and choriocapillaris layers was measured.
Results: Twelve eyes Commercial Convection Ovens of 12 patients were included into the study.The most consistent OCTA sign at baseline was the presence of a vascular tuft in the outer retina (100%).The highest response was achieved at 3 months, with statistically significant decrease in lesion detection in the outer retina, in the choriocapillaris, and outer retinal lesion size.
At 6 months, 58% of outer retinal lesions had disappeared.Conclusions: Brolucizumab IVI shows a good short-term efficacy for the treatment of type 3 neovascularizations.Further studies with greater number of patients and longer follow-up are warranted to confirm these findings.